Increased keratinocyte activity and Piezo1 signaling contribute to paclitaxel-induced mechanical hypersensitivity
Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu HE, Stucky CL, 2024
Science Translational Medicine 16:eadn5629
High-speed imaging of evoked rodent mechanical behaviors yields variable results that are not predictive of inflammatory injury
Rodriguez Garcia DM, Szabo A, Mikesell AR, Zorn SJ, Tsafack UK, Sriram A, Waltz TB, Enders JD, Mecca CM, Stucky CL, Sadler KE, 2024
Pain 165(7): 1569-1582
Peripheral transient receptor potential vanilloid type 4 hypersensitivity contributes to chronic sickle cell disease pain
Ehlers VE, Sadler KE, Stucky CL, 2023
Pain 164(8): 1874-1886
Keratinocyte PIEZO1 modulates cutaneous mechanosensation
Mikesell AR, Isaeva O, Moehring F, Sadler KE, Menzel AD, Stucky CL, 2022
eLife 11:e65987
Contextual control of conditioned pain tolerance and endogenous analgesic systems
Trask S, Mogil JS, Helmstetter FJ, Stucky CL, Sadler KE, 2022
eLife 11:e75283
Sensory-specific peripheral nerve pathology in a rat model of Fabry disease
Waltz TB, Burand AJ, Sadler KE, Stucky CL, 2021
Neurobiology of Pain 10:100074
Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice
Sadler KE, Moehring F, Shiers SI, Laskowski LJ, Mikesell AR, Plautz ZR, Brezinski AN, Mecca CM, Dussor G, Price TJ, McCorvy JD, Stucky CL, 2021
Science Translational Medicine 13:eabd7702
our paper featured on cover!
Keratinocytes contribute to normal cold and heat sensation
Sadler KE, Moehring F, Stucky CL, 2020
eLife 9:e58625
Peripheral nerve pathology in sickle cell disease mice
Sadler KE, Lewis TR, Waltz TB, Besharse JC, Stucky CL, 2019
Pain Reports 4(4): e765
Gabapentin alleviates chronic spontaneous pain and acute hypoxia-related pain in a mouse model of sickle cell disease
Sadler KE, Langer SN, Menzel AD, Moehring F, Erb AN, Brandow AM, Stucky CL, 2019
British Journal of Haematology 187: 246-260
Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice
Sadler KE, Zappia KJ, O'Hara CL, Langer SN, Weyer AD, Hillery CA, Stucky CL, 2018
Pain 159: 1652-1663
Kate's Graduate Work
Central amygdala expression of metabotropic glutamate receptor 5 linked to age-dependent changes in pain sensitivity
Sadler KE, Gartland N, Cavanaugh JE, Kolber BJ, 2017
Neurobiology of Aging S0197-4580(17): 30131-30138
Divergent functions of the left and right central amygdala in visceral nociception
Sadler KE, McQuaid NA, Cox AC, Behun MN, Trouten AN, Kolber BJ, 2017
Pain 158(4): 747-759
Post-inflammatory hyperpigmentation following human cold pain testing
Wolz MJ, Sadler KE, Long CC, Brenner DS, Kim BS, Gereau RW IV, Kolber BJ, 2016
Pain Reports 1: e569
Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice
Long CC, Sadler KE, Kolber BJ, 2016
Physiology and Behavior 16: 278-285
Urinary bladder distension evoked visceromotor responses as a model for bladder pain
Sadler KE, Stratton JM, Kolber BJ, 2014
JoVE 86: e51413
Optimization of a pain model: effects of body temperature and anesthesia on bladder nociception in mice
Sadler KE, Stratton JM, DeBerry JJ, Kolber BJ, 2013
PLoS One 8(11): e79617
Central amygdala mGluR5 in the modulation of visceral pain
Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW IV, 2012
Journal of Neuroscience 32(41): 14217-14226
Preprints
Gut microbiota and metabolites drive chronic sickle cell disease pain
Sadler KE, Atkinson SN, Ehlers VL, Waltz TB, Hayward M, Rodriguez Garcia DM, Salzman NH, Stucky CL, Brandow AM
bioRxiv, 2023
Review Articles + Book Chapters
Microbiome contributions to pain: a review of the preclinical literature
Pratt ML, Plumb AN, Manjrekar A, Cardona LM, John JM, Sadler KE, 2025
Pain 166:262-281
Innovations and advances in modeling and measuring pain in animals
Sadler KE, Mogil JS, Stucky CL, 2022
Nature Reviews Neuroscience 23:70-85
Ex vivo skin-teased fiber recordings from tibial nerve
Sadler KE, Patitucci TN, Stucky CL, 2022
In Contemporary Approaches to the Study of Pain: from Molecules to Neural Networks, Springer Nature, New York
Neuronal transient receptor potential (TRP) channels and noxious sensory detection in sickle cell disease
Sadler KE and Stucky CL, 2019
Neuroscience Letters 694: 184-191
Commentaries
Bug in the syndrome: Using the gut microbiome to diagnose complex regional pain syndrome
Manjarres Z, Plumb AN, Sadler KE, 2025
Anesthesiology 143(1):20-21
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Commentary on Gonzalez et al. (2025) "Altered gut microbiome composition and function in individuals with complex regional pain syndrome"
A humanized focus on sickle cell pain
Sadler KE and Price TJ, 2024
Blood 143(20):2016-2017
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Commentary on Allison et al. (2024) "Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient plasma"
Blocking COX-2 for sickle cell pain relief
Sadler KE and Stucky CL, 2019
Blood 133(18):1924-1925
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Commentary on Khasabova et al. (2019) "Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease"